| Batsman | Sixes (6s) | Innings |
| G Maxwell (Aus) | 14 | 4 |
| KL Rahul (Ind) | 11 | 7 |
| J Bairstow (Eng) | 11 | 8 |
| Liton Das (Ban) | 10 | 3 |
| A Finch (Aus) | 10 | 11 |
| T Iqbal (Ban) | 9 | 3 |
| M Guptill (NZ) | 8 | 4 |
| Evin Lewis (WI) | 7 | 3 |
| D Tiripano (Zim) | 7 | 4 |
| P Stirling (Ire) | 7 | 6 |
| S Smith (Aus) | 7 | 7 |
| E Morgan (Eng) | 7 | 8 |
| R Sharma (Ind) | 6 | 3 |
| C Williams (Nam) | 6 | 3 |
| R Taylor (NZ) | 6 | 4 |
| K Pollard (WI) | 6 | 5 |
| Joe Denly (Eng) | 5 | 2 |
| D Willey (Eng) | 5 | 2 |
| Kushal Malla (Nep) |
5 | 2 |
| H Klaasen (SA) | 5 | 3 |
| D Miller (SA) | 5 | 4 |
| N Khushi (Oman) | 5 | 4 |
| Suraj Kumar (Oman) | 5 | 4 |
| Sikandar Raza (Zim) | 5 | 6 |
| B Taylor (Zim) | 5 | 6 |
| Q de Kock (SA) | 5 | 6 |
| H Pandya (Ind) | 4 | 1 |
| Nisarg Patel (USA) |
4 | 2 |
| Fabian Allen (WI) |
4 | 2 |
| J Malan (SA) | 4 | 3 |
| S Goud (Oman) | 4 | 3 |
| Sam Billings (Eng) | 4 | 6 |
| Z Maqsood (Oman) | 4 | 6 |
| D Warner (Aus) | 4 | 11 |
| M Saifuddin (Ban) | 3 | 1 |
| W Riaz (Pak) | 3 | 2 |
| M Usman (UAE) | 3 | 2 |
| Babar Azam (Pak) | 3 | 3 |
| N Saini (Ind) | 3 | 3 |
| K Verreynne (SA) | 3 | 3 |
| C de Grandhomme (NZ) | 3 | 4 |
| T Bavuma (SA) | 3 | 4 |
| R Jadeja (Ind) | 3 | 5 |
| M Nadeem (Oman) | 3 | 5 |
| A Balbirnie (Ire) | 3 | 6 |
| A Ilyas (Oman) | 3 | 6 |
| N Pooran (WI) | 3 | 6 |
| V Kohli (Ind) | 3 | 7 |
| S Iyer (Ind) | 3 | 7 |
| Jason Roy (Eng) | 3 | 8 |
| A Carey (Aus) | 3 | 10 |
| H Sohail (Pak) | 2 | 1 |
| Imad Wasim (Pak) | 2 | 1 |
| K Jamieson (NZ) | 2 | 1 |
| Haider Ali (Pak) | 2 | 2 |
| Najmul Hossain (Ban) |
2 | 2 |
| M Mithun (Ban) | 2 | 2 |
| S Dhawan (Ind) | 2 | 3 |
| Kamunhukamwe (Zim) | 2 | 3 |
| Darren Bravo (WI) |
2 | 3 |
| W Hasaranga (SL) | 2 | 3 |
| B Bhandari (Nep) | 2 | 3 |
| Prithvi Shaw (Ind) | 2 | 3 |
| Kusal Mendis (SL) |
2 | 3 |
| S Lamichhane (Nep) | 2 | 3 |
| JJ Smit (Nam) | 2 | 3 |
| M Adair (Ire) | 2 | 3 |
| Tom Latham (NZ) | 2 | 4 |
| P Khadka (Nep) | 2 | 4 |
| DS Airee (Nep) | 2 | 4 |
| A Homraj (USA) | 2 | 4 |
| J Neesham (NZ) | 2 | 4 |
| Sean Williams (Zim) | 2 | 5 |
| A McBrine (Ire) | 2 | 5 |
| Adil Rashid (Eng) | 2 | 5 |
| Tom Banton (Eng) | 2 | 5 |
| Kevin O’Brien (Ire) |
2 | 6 |
| M Starc (Aus) | 2 | 8 |
| P Cummins (Aus) | 2 | 9 |
| K Pierre (WI) | 1 | 1 |
| R Pant (Ind) | 1 | 1 |
| M Santner (NZ) | 1 | 2 |
| K Richardson (Aus) | 1 | 2 |
| Mehidy Hasan (Ban) | 1 | 2 |
| Keemo Paul (WI) | 1 | 2 |
| K Jadhav (Ind) | 1 | 2 |
| Bilal Khan (Oman) | 1 | 2 |
| M Sanuth (Oman) | 1 | 2 |
| R Mustafa (UAE) | 1 | 2 |
| R Shepherd (WI) | 1 | 2 |
| Waheed Ahmed (UAE) |
1 | 2 |
| B Muzarabani (Zim) | 1 | 2 |
| B Chari (Zim) | 1 | 3 |
| Iftikhar Ahmed (Pak) |
1 | 3 |
| JJ Smuts (SA) | 1 | 3 |
| M Shami (Ind) | 1 | 3 |
| Mahmudullah (Ban) | 1 | 3 |
| S Cottrell (WI) | 1 | 3 |
| Avishka Fernando (SL) |
1 | 3 |
| H Walsh (WI) | 1 | 3 |
| Thisara Perera (SL) |
1 | 3 |
| B King (WI) | 1 | 3 |
| Chirag Suri (UAE) | 1 | 3 |
| V Aravind (UAE) | 1 | 3 |
| B McCarthy (Ire) | 1 | 4 |
| S Ambris (WI) | 1 | 4 |
| M Agarwal (Ind) | 1 | 4 |
| M Stoinis (Aus) | 1 | 4 |
| G Malla (Nep) | 1 | 4 |
| X Marshall (USA) | 1 | 4 |
| S Netravalkar (USA) | 1 | 4 |
| C Mumba (Zim) | 1 | 5 |
| G Delany (Ire) | 1 | 5 |
| Tom Curran (Eng) | 1 | 5 |
| Joe Root (Eng) | 1 | 5 |
| R Chase (WI) | 1 | 5 |
| W Madhevere (Zim) | 1 | 6 |
| Khawar Ali (Oman) | 1 | 6 |
| M Marsh (Aus) | 1 | 7 |
Related: Leading runs in ODI this year
Glossary: Aus-Australia, Ind-India, Ire-Ireland, Nam-Namibia, UAE-United Arab Emirates, WI-West Indies