| Batsman | Sixes (6s) | Innings |
| J Malhotra (USA) | 22 | 6 |
| P Stirling (Ire) | 17 | 14 |
| J Bairstow (Eng) | 15 | 5 |
| B Stokes (Eng) | 13 | 5 |
| F Zaman (Pak) | 13 | 6 |
| Mahmudullah (Ban) | 13 | 11 |
| W Hasaranga (SL) | 13 | 14 |
| R Gurbaz (Afg) | 12 | 3 |
| R Pant (Ind) | 11 | 2 |
| Janneman Malan (SA) |
11 | 6 |
| Steven Taylor (USA) | 10 | 6 |
| Evin Lewis (WI) | 9 | 6 |
| A Markram (SA) | 9 | 7 |
| H Tector (Ire) | 9 | 14 |
| Rashid Khan (Afg) | 8 | 2 |
| H Pandya (Ind) | 8 | 5 |
| Jatinder Singh (Oman) | 8 | 5 |
| Q de Kock (SA) | 7 | 3 |
| Hasan Ali (Pak) | 7 | 4 |
| Z Maqsood (Oman) | 7 | 5 |
| Babar Azam (Pak) | 7 | 6 |
| Darren Bravo (WI) |
7 | 6 |
| T Iqbal (Ban) | 7 | 12 |
| KL Rahul (Ind) | 6 | 3 |
| K Pollard (WI) | 6 | 5 |
| R Paudel (Nep) | 6 | 6 |
| Van der Dussen (SA) |
6 | 7 |
| G Munsey (Sco) | 5 | 3 |
| M Guptill (NZ) | 5 | 3 |
| Rovman Powell (WI) |
5 | 3 |
| KC Karan (Nep) | 5 | 4 |
| N Vanua (PNG) | 5 | 4 |
| Suraj Kumar (Oman) | 5 | 5 |
| G Malla (Nep) | 5 | 6 |
| Avishka Fernando (SL) |
5 | 8 |
| C Karunaratne (SL) | 5 | 9 |
| L Tucker (Ire) | 5 | 10 |
| Van der Gugten (Ned) |
4 | 2 |
| E Hutchinson (USA) | 4 | 3 |
| L Livingstone (Eng) | 4 | 3 |
| R Burl (Zim) | 4 | 3 |
| N Khushi (Oman) | 4 | 4 |
| N Pooran (WI) | 4 | 5 |
| D Gunathilaka (SL) | 4 | 6 |
| K Bhurtel (Nep) | 4 | 6 |
| Monank Patel (USA) | 4 | 6 |
| C Asalanka (SL) | 4 | 8 |
| D Shanaka (SL) | 4 | 12 |
| L Gregory (Eng) | 3 | 2 |
| M Usman (UAE) | 3 | 2 |
| S Thakur (Ind) | 3 | 2 |
| A Afghan (Afg) | 3 | 3 |
| D Miller (SA) | 3 | 3 |
| J Ahmadi (Afg) | 3 | 3 |
| K Verreynne (SA) | 3 | 3 |
| M Marsh (Aus) | 3 | 3 |
| M Wade (Aus) | 3 | 3 |
| Moeen Ali (Eng) | 3 | 3 |
| R Berrington (Sco) | 3 | 3 |
| Sam Curran (Eng) | 3 | 3 |
| Sohaib Maqsood (Pak) |
3 | 3 |
| Sikandar Raza (Zim) | 3 | 4 |
| R Chakabva (Zim) | 3 | 5 |
| S Goud (Oman) | 3 | 5 |
| S Myburgh (Ned) | 3 | 5 |
| Shai Hope (WI) | 3 | 5 |
| A Joseph (WI) | 3 | 6 |
| Afif Hossain (Ban) | 3 | 6 |
| S Dhawan (Ind) | 3 | 6 |
| G Dockrell (Ire) | 3 | 8 |
| Mushfiqur (Ban) | 3 | 9 |
| A Balbirnie (Ire) | 3 | 14 |
| A Turner (Aus) | 2 | 2 |
| D Mitchell (NZ) | 2 | 2 |
| I Kishan (Ind) | 2 | 2 |
| Wes Agar (Aus) | 2 | 2 |
| A Carey (Aus) | 2 | 3 |
| E Morgan (Eng) | 2 | 3 |
| I Udana (SL) | 2 | 3 |
| J Philippe (Aus) | 2 | 3 |
| Rahmat Shah (Afg) | 2 | 3 |
| Kaleemullah (Oman) | 2 | 3 |
| Kusal Mendis (SL) | 2 | 3 |
| Mahedi Hasan (Ban) | 2 | 3 |
| D Chandimal (SL) | 2 | 4 |
| Jason Roy (Eng) | 2 | 4 |
| K Pandya (Ind) | 2 | 4 |
| M Nadeem (Oman) | 2 | 4 |
| Ayaan Khan (Oman) | 2 | 5 |
| B Rajapaksa (SL) | 2 | 5 |
| B Taylor (Zim) | 2 | 5 |
| Damien Ravu (PNG) | 2 | 5 |
| J Holder (WI) | 2 | 5 |
| K Rabada (SA) | 2 | 5 |
| Shadab Khan (Pak) | 2 | 5 |
| W Madhevere (Zim) | 2 | 5 |
| C Campher (Ire) | 2 | 6 |
| Lega Siaka (PNG) | 2 | 6 |
| M Adair (Ire) | 2 | 6 |
| M Mithun (Ban) | 2 | 7 |
| A Phehlukwayo (SA) | 2 | 8 |
| Simi Singh (Ire) | 2 | 9 |
| D Chameera (SL) | 2 | 12 |
| Aarif Sheikh (Nep) | 1 | 1 |
| Aaron Jones (USA) | 1 | 1 |
| Ahmed Raza (UAE) | 1 | 1 |
| D Chahar (Ind) | 1 | 1 |
| D Dupavillon (SA) | 1 | 1 |
| Gulsan Jha (Nep) | 1 | 1 |
| Fabian Allen (WI) | 1 | 1 |
| K Prajapati (Oman) | 1 | 1 |
| Kashif Daud (UAE) | 1 | 1 |
| S Samson (Ind) | 1 | 1 |
| V Kingma (Ned) | 1 | 1 |
| A Paradkar (USA) | 1 | 2 |
| C Ervine (Zim) | 1 | 2 |
| C Rizwan (UAE) | 1 | 2 |
| G Naib (Afg) | 1 | 2 |
| Shoriful Islam (Ban) |
1 | 2 |
| Gajanand Singh (USA) | 1 | 2 |
| H Shahidi (Afg) | 1 | 2 |
| K Ottley (WI) | 1 | 2 |
| M Nabi (Afg) | 1 | 2 |
| N Zadran (Afg) | 1 | 2 |
| Waheed Ahmed (UAE) |
1 | 2 |
| D Karunaratne (SL) | 1 | 3 |
| K Coetzer (Sco) | 1 | 3 |
| K Mayers (WI) | 1 | 3 |
| M Cross (Sco) | 1 | 3 |
| M Pandey (Ind) | 1 | 3 |
| Ramesh Mendis (SL) | 1 | 3 |
| S Ambris (WI) | 1 | 3 |
| S Krishnamurthi (USA) | 1 | 3 |
| S Lamichhane (Nep) | 1 | 3 |
| T Marumani (Zim) | 1 | 3 |
| V Kohli (Ind) | 1 | 3 |
| B Bhandari (Nep) | 1 | 4 |
| Jason Kila (PNG) | 1 | 4 |
| S Sarkar (Ban) | 1 | 4 |
| A Bandara (SL) | 1 | 5 |
| Gaudi Toka (PNG) | 1 | 5 |
| Karima Gore (USA) | 1 | 5 |
| Kusal Perera (SL) | 1 | 5 |
| L van Beek (Ned) | 1 | 5 |
| M O’Dowd (Ned) | 1 | 5 |
| S Edwards (Ned) | 1 | 5 |
| Sese Bau (PNG) | 1 | 5 |
| Aasif Sheikh (Nep) | 1 | 6 |
| Assad Vala (PNG) | 1 | 6 |
| Faheem Ashraf (Pak) | 1 | 6 |
| Imam-ul-Haq (Pak) | 1 | 6 |
| Mehidy Hasan (Ban) | 1 | 6 |
| W Porterfield (Ire) | 1 | 6 |
| H Klaasen (SA) | 1 | 7 |
| A McBrine (Ire) | 1 | 9 |
| Shakib (Ban) | 1 | 9 |
Related: Leading runs in one-dayers this year
Glossary: Aus-Australia, Ban-Bangladesh, Eng-England, Ind-India, Nam-Namibia, Ned-Netherlands, Nep-Nepal, NZ-New Zealand, Pak-Pakistan, PNG-Papua New Guinea, Sco-Scotland, SA-South Africa, SL-Sri Lanka, UAE-United Arab Emirates, USA-United States of America, WI-West Indies, Zim-Zimbabwe