| Batsman | Sixes (6s) | Innings |
| J Bairstow (Eng) | 14 | 3 |
| P Stirling (Ire) | 14 | 5 |
| F Zaman (Pak) | 13 | 3 |
| R Gurbaz (Afg) | 12 | 3 |
| R Pant (Ind) | 11 | 2 |
| B Stokes (Eng) | 11 | 3 |
| Rashid Khan (Afg) | 8 | 2 |
| H Pandya (Ind) | 8 | 3 |
| Mahmudullah (Ban) | 8 | 5 |
| W Hasaranga (SL) | 7 | 3 |
| Van der Dussen (SA) |
6 | 2 |
| KL Rahul (Ind) | 6 | 3 |
| Evin Lewis (WI) | 6 | 3 |
| Darren Bravo (WI) |
6 | 3 |
| M Guptill (NZ) | 5 | 3 |
| Rovman Powell (WI) |
5 | 3 |
| Hasan Ali (Pak) | 4 | 1 |
| A Markram (SA) | 4 | 3 |
| L Tucker (Ire) | 4 | 5 |
| K Verreynne (SA) | 3 | 1 |
| D Miller (SA) | 3 | 2 |
| M Usman (UAE) | 3 | 2 |
| Sam Curran (Eng) | 3 | 2 |
| L Livingstone (Eng) | 3 | 2 |
| Moeen Ali (Eng) | 3 | 2 |
| S Thakur (Ind) | 3 | 2 |
| Babar Azam (Pak) | 3 | 3 |
| Shai Hope (WI) | 3 | 3 |
| D Gunathilaka (SL) | 3 | 3 |
| A Afghan (Afg) | 3 | 3 |
| J Ahmadi (Afg) | 3 | 3 |
| T Iqbal (Ban) | 3 | 6 |
| Q de Kock (SA) | 2 | 2 |
| D Mitchell (NZ) | 2 | 2 |
| K Pollard (WI) | 2 | 2 |
| N Pooran (WI) | 2 | 2 |
| S Dhawan (Ind) | 2 | 3 |
| Jason Roy (Eng) | 2 | 3 |
| K Pandya (Ind) | 2 | 3 |
| A Phehlukwayo (SA) | 2 | 3 |
| M Mithun (Ban) | 2 | 3 |
| Rahmat Shah (Afg) | 2 | 3 |
| D Chandimal (SL) | 2 | 3 |
| Mahedi Hasan (Ban) | 2 | 3 |
| Simi Singh (Ire) | 2 | 4 |
| Mushfiqur (Ban) | 2 | 6 |
| Ahmed Raza (UAE) | 1 | 1 |
| D Dupavillon (SA) | 1 | 1 |
| E Morgan (Eng) | 1 | 1 |
| F Allen (WI) | 1 | 1 |
| Kashif Daud (UAE) | 1 | 1 |
| C Rizwan (UAE) | 1 | 2 |
| G Naib (Afg) | 1 | 2 |
| Shadab Khan (Pak) | 1 | 2 |
| H Shahidi (Afg) | 1 | 2 |
| J Holder (WI) | 1 | 2 |
| K Ottley (WI) | 1 | 2 |
| M Nabi (Afg) | 1 | 2 |
| N Zadran (Afg) | 1 | 2 |
| Waheed Ahmed (UAE) |
1 | 2 |
| V Kohli (Ind) | 1 | 3 |
| Imam-ul-Haq (Pak) | 1 | 3 |
| A Joseph (WI) | 1 | 3 |
| K Mayers (WI) | 1 | 3 |
| A Bandara (SL) | 1 | 3 |
| D Karunaratne (SL) | 1 | 3 |
| S Ambris (WI) | 1 | 3 |
| S Sarkar (Ban) | 1 | 4 |
| C Campher (Ire) | 1 | 5 |
| H Tector (Ire) | 1 | 5 |
Related: Leading runs in one-dayers this year
Glossary: Aus-Australia, Ban-Bangladesh, Eng-England, Ind-India, Nam-Namibia, NZ-New Zealand, Pak-Pakistan, SA-South Africa, SL-Sri Lanka, UAE-United Arab Emirates, WI-West Indies, Zim-Zimbabwe