| Batsman | Sixes (6s) | Innings |
| P Stirling (Ire) | 14 | 5 |
| R Gurbaz (Afg) | 12 | 3 |
| Rashid Khan (Afg) | 8 | 2 |
| Rovman Powell (WI) |
5 | 3 |
| L Tucker (Ire) | 4 | 5 |
| M Usman (UAE) | 3 | 2 |
| Mahmudullah (Ban) | 3 | 2 |
| A Afghan (Afg) | 3 | 3 |
| J Ahmadi (Afg) | 3 | 3 |
| T Iqbal (Ban) | 2 | 3 |
| Rahmat Shah (Afg) | 2 | 3 |
| Mushfiqur (Ban) | 2 | 3 |
| Simi Singh (Ire) | 2 | 4 |
| Ahmed Raza (UAE) | 1 | 1 |
| Kashif Daud (UAE) | 1 | 1 |
| C Rizwan (UAE) | 1 | 2 |
| G Naib (Afg) | 1 | 2 |
| H Shahidi (Afg) | 1 | 2 |
| K Ottley (WI) | 1 | 2 |
| M Nabi (Afg) | 1 | 2 |
| N Zadran (Afg) | 1 | 2 |
| Waheed Ahmed (UAE) |
1 | 2 |
| A Joseph (WI) | 1 | 3 |
| K Mayers (WI) | 1 | 3 |
| S Ambris (WI) | 1 | 3 |
| C Campher (Ire) | 1 | 5 |
| H Tector (Ire) | 1 | 5 |
Related: Leading runs in one-dayers this year
Glossary: Aus-Australia, Ban-Bangladesh, Eng-England, Ind-India, Nam-Namibia, NZ-New Zealand, Pak-Pakistan, SA-South Africa, SL-Sri Lanka, UAE-United Arab Emirates, WI-West Indies, Zim-Zimbabwe