| Bowler | Wickets | Inns | Overs | BBI | ER |
| A Aman (Bihar) |
14 | 5 | 20 | 4/9 | 4.55 |
| Avesh Khan (Madhya Pradesh) |
14 | 5 | 20 | 5/17 | 7.45 |
| Ishan Porel (Bengal) |
13 | 5 | 19 | 4/24 | 7.42 |
| C Sakariya (Saurashtra) |
12 | 5 | 20 | 5/11 | 4.90 |
| L Meriwala (Baroda) |
11 | 5 | 18.3 | 5/8 | 6.27 |
| R Chahar (Maharashtra) |
11 | 5 | 20 | 5/14 | 6.55 |
| D Nalkande (Vidarbha) |
11 | 5 | 18 | 4/20 | 8.33 |
| J Saxena (Kerala) |
10 | 5 | 19 | 3/13 | 6.26 |
| S Kaul (Punjab) |
10 | 4 | 15 | 4/26 | 7.26 |
| Pritam Das (Assam) |
10 | 5 | 17 | 3/27 | 8.23 |
Glossary: BBI-Best bowling innings, Inns-Innings, ER-Economy rate
Related: SMAT 2021 batting record