| Batsman | Sixes (6s) | Innings |
| Odean Smith (WI) | 14 | 5 |
| N Vanua (PNG) | 11 | 9 |
| Kashif Daud (UAE) | 10 | 10 |
| T Head (Aus) | 8 | 3 |
| Shoaib Khan (Oman) | 8 | 10 |
| Jatinder Singh (Oman) | 8 | 12 |
| Imam-ul-Haq (Pak) | 7 | 3 |
| M Leask (Sco) | 7 | 3 |
| Will Young (NZ) | 7 | 3 |
| Q de Kock (SA) | 7 | 5 |
| R Gurbaz (Afg) | 7 | 6 |
| Chirag Suri (UAE) | 7 | 11 |
| JJ Smit (Nam) | 6 | 5 |
| N Zadran (Afg) | 6 | 6 |
| Van der Dussen (SA) |
6 | 6 |
| N Khushi (Oman) | 6 | 9 |
| Ayaan Khan (Oman) | 6 | 10 |
| M Waseem (UAE) | 6 | 11 |
| B McDermott (Aus) | 5 | 3 |
| Tom Latham (NZ) | 5 | 3 |
| G Munsey (Sco) | 5 | 4 |
| H Shahidi (Afg) | 5 | 6 |
| S Brooks (WI) | 5 | 6 |
| Z Maqsood (Oman) | 5 | 10 |
| D Chahar (Ind) | 4 | 2 |
| D Shanaka (SL) | 4 | 3 |
| L van Beek (Ned) | 4 | 3 |
| D Miller (SA) | 4 | 4 |
| K Pollard (WI) | 4 | 4 |
| D Wiese (Nam) | 4 | 5 |
| G Erasmus (Nam) | 4 | 5 |
| J Holder (WI) | 4 | 6 |
| Rahmat Shah (Afg) | 4 | 6 |
| B Hameed (UAE) | 4 | 10 |
| V Aravind (UAE) | 4 | 11 |
| Mark Adair (Ire) | 3 | 2 |
| C Asalanka (SL) | 3 | 3 |
| M Usman (UAE) | 3 | 3 |
| D Bracewell (NZ) | 4 | 2 |
| Mehidy Hasan (Ban) | 4 | 4 |
| R Paudel (Nep) | 4 | 6 |
| Kaleemullah (Oman) | 4 | 8 |
| R Mustafa (UAE) | 4 | 9 |
| Dev Khanal (Nep) | 3 | 2 |
| K Verreynne (SA) | 3 | 3 |
| M Rippon (Ned) | 3 | 3 |
| M Stoinis (Aus) | 3 | 3 |
| R Berrington (Sco) | 3 | 4 |
| R Trumpelmann (Nam) | 3 | 4 |
| A Joseph (WI) | 3 | 6 |
| Liton Das (Ban) | 3 | 6 |
| R Pant (Ind) | 3 | 6 |
| Shakib (Ban) | 3 | 6 |
| K Prajapati (Oman) | 3 | 12 |
| Ish Sodhi (NZ) | 2 | 2 |
| Khushdil Shah (Pak) | 2 | 2 |
| P Stirling (Ire) | 2 | 2 |
| A McBrine (Ire) | 2 | 3 |
| C Ackermann (Ned) | 2 | 3 |
| Cameron Green (Aus) |
2 | 3 |
| F Zaman (Pak) | 2 | 3 |
| H Tector (Ire) | 2 | 3 |
| KC Karan (Nep) | 2 | 3 |
| L Ngidi (SA) | 2 | 3 |
| M Guptill (NZ) | 2 | 3 |
| R Chakabva (Zim) | 2 | 3 |
| Riaz Hassan (Afg) | 2 | 3 |
| S Thakur (Ind) | 2 | 3 |
| Sean Williams (Zim) | 2 | 3 |
| Afif Hossain (Ban) | 2 | 4 |
| KL Rahul (Ind) | 2 | 4 |
| Yasir Ali (Ban) | 2 | 4 |
| Rashid Khan (Afg) | 2 | 5 |
| N Pooran (WI) | 2 | 6 |
| Ahmed Raza (UAE) | 2 | 7 |
| S Goud (Oman) | 2 | 8 |
| Lega Siaka (PNG) | 2 | 9 |
| R Hekure (PNG) | 2 | 9 |
| Tony Ura (PNG) | 2 | 10 |
| Khawar Ali (Oman) | 2 | 11 |
| A Balbirnie (Ire) | 1 | 1 |
| B Sharki (Nep) | 1 | 1 |
| I Kishan (Ind) | 1 | 1 |
| Ibrahim Zadran (Afg) |
1 | 1 |
| Jason Kila (PNG) | 1 | 1 |
| R Ngarava (Zim) | 1 | 1 |
| B Sharki (Nep) | 1 | 2 |
| D Chameera (SL) | 1 | 2 |
| D Pretorius (SA) | 1 | 2 |
| R Ashwin (Ind) | 1 | 2 |
| V Iyer (Ind) | 1 | 2 |
| W Sundar (Ind) | 1 | 2 |
| A Carey (Aus) | 1 | 3 |
| A Finch (Aus) | 1 | 3 |
| Babar Azam (Pak) | 1 | 3 |
| Brandon King (WI) | 1 | 3 |
| D Chandimal (SL) | 1 | 3 |
| Fabian Allen (WI) | 1 | 3 |
| Fayyaz Butt (Oman) | 1 | 3 |
| G Delany (Ire) | 1 | 3 |
| G Dockrell (Ire) | 1 | 3 |
| G Naib (Afg) | 1 | 3 |
| H Nicholls (NZ) | 1 | 3 |
| K Maharaj (SA) | 1 | 3 |
| Kamindu Mendis (SL) | 1 | 3 |
| R Sharma (Ind) | 1 | 3 |
| R Taylor (NZ) | 1 | 3 |
| S Abbott (Aus) | 1 | 3 |
| S Dhawan (Ind) | 1 | 3 |
| S Myburgh (Ned) | 1 | 3 |
| Sikandar Raza (Zim) | 1 | 3 |
| T Kaitano (Zim) | 1 | 3 |
| Vikramjit (Ned) | 1 | 3 |
| W Porterfield (Ire) | 1 | 3 |
| J Frylinck (Nam) | 1 | 4 |
| M Cross (Sco) | 1 | 4 |
| M Nadeem (Oman) | 1 | 4 |
| S Lamichhane (Nep) | 1 | 4 |
| SK Yadav (Ind) | 1 | 4 |
| A Hosein (WI) | 1 | 5 |
| Asif Khan (UAE) | 1 | 5 |
| C Williams (Nam) | 1 | 5 |
| Mahmudullah (Ban) | 1 | 5 |
| S Baard (Nam) | 1 | 5 |
| Janneman Malan (SA) |
1 | 6 |
| K Bhurtel (Nep) | 1 | 6 |
| P Seelaar (Ned) | 1 | 6 |
| S Edwards (Ned) | 1 | 6 |
| Shai Hope (WI) | 1 | 6 |
| T Bavuma (SA) | 1 | 6 |
| T Iqbal (Ban) | 1 | 6 |
| Chad Soper (PNG) | 1 | 8 |
| C Amini (PNG) | 1 | 10 |
Related: Leading runs in one-dayers this year
Glossary: Afg-Afghanistan, Aus-Australia, Ban-Bangladesh, Eng-England, Ind-India, Nam-Namibia, Ned-Netherlands, Nep-Nepal, NZ-New Zealand, Pak-Pakistan, PNG-Papua New Guinea, Sco-Scotland, SA-South Africa, SL-Sri Lanka, UAE-United Arab Emirates, USA-United States of America, WI-West Indies, Zim-Zimbabwe